Product Data SheetProduct Name:CAS No.: Cat. No.:MWt:Formula:Purity :MLN4924 hydrochloride1160295-21-5HY-10484479.98C21H26ClN5O4S>98%Solubility:DMSOMechanisms: Pathways:Others ; Target:NAE gyBiological Activity:MLN4924 is a potent and selective small molecule NEDD8-activating enzyme (NAE) inhibitor.References:[1]. Michael A. Milhollen et al MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuselarge B-cell lymphoma models: rationale for treatment of NF-κB-dependent lymphoma BloodSeptember 2, 2010 vol. 116 no. 91515-1523 [][2]. Jie Jessie Lin et al NEDD8-Targeting Drug MLN4924 Elicits DNA Rereplication by StabilizinggggpygCdt1 in S Phase, Triggering Checkpoint Activation, Apoptosis, and Senescence in Cancer CellsCancer Res December 15, 2010 70; 10310 [3]. Zhao Y, Xiong X, Jia L, Sun Y.Targeting Cullin-RING ligases by MLN4924 induces autophagyvia modulating the HIF1-REDD1-TSC1-mTORC1-DEPTOR axis.Cell Death Dis. 2012 Sep 6;3:e386. [4]. Nawrocki ST, Griffin P, Kelly KR, Carew JS.MLN4924 : a novel first-in-class inhibitor of NEDD8-activating enzyme for cancer therapy.Expert Opin Investig Drugs. 2012 Jul 16. [5]. Toth JI, Yang L, Dahl R, Petroski MD.A Gat...Caution: Not fully tested. For research purposes onlyMedchemexpress LLCwww.medchemexpress.com 18 Wilkinson Way, Princeton, NJ 08540,USAEmail: info@medchemexpress.com Web: www.medchemexpress.com