PIPERAZINYLACYLPIPERIDINE DERIVATIVES, THEIR PREPA

专利名称：PIPERAZINYLACYLPIPERIDINE DERIVATIVES,

THEIR PREPARATION AND THERAPEUTICUSE THEREOF

发明人：BONO, FRANCOISE,BOSCH, MICHAEL,DOS

SANTOS, VICTOR,HERBERT, JEAN,MARC,NISATO, DINO,TONNERRE,BERNARD,WAGNON, JEAN

申请号：EP03757109.8申请日：20030605公开号：EP1513836A1公开日：20050316

摘要：The invention concerns 1-substituted piperazinylacylpiperidine derivatives, ofgeneral formula (I), wherein: n is 1 or 2; R1 represents a halogen atom, a trifluoromethylradical, a C1-C4 alkyl, a C1-C4 alkoxy, a trifluoromethoxy radical; R2 represents ahydrogen atom or a halogen atom; R3 represents a hydrogen atom, an -OR5 group; a -CH2OR5 group; a -NR6R7 group; a -NR8COR9 group; a -NR8CONR10R11 group; a -CH2NR12R13 group; a -CH2NR8CONR14R15 group; a C1-C4 alkoxycarbonyl; a -CONR16R17 group; or R3 forms a double bond between the carbon atom whereto it isbound and the neighbouring carbon atom of the piperidine cycle; R4 represents thearomatic 1,3-thiazol-2-yl group of formula (II). The invention also concerns a method forpreparing said compounds and their therapeutic use.

申请人：SANOFI-AVENTIS

地址：174, Avenue de France 75013 Paris FR

国籍：FR

代理机构：Tsitini-Souleau, Maria

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